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Cytokine Production by Tumor Bioptate at Different Pathological Prognostic Stages in Breast Cancer

  • BIOCHEMISTRY, BIOPHYSICS, AND MOLECULAR BIOLOGY
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Abstract

Differences in the production of cytokines by tumor biopsy specimens were revealed depending on the pathological prognostic stages of The American Joint Committee on Cancer (AJCC) of invasive nonspecific breast carcinoma (INBC). The patients with a predominant absence of metastases in combination with a triple negative molecular subtype differ from the patients with other pathological prognostic stages in the cytokine-producing tumor resource of IL-18, IL-1β, IL-1Ra, TNF-α, GM-CSF, and MCP-1.

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Funding

The study was performed under the State Assignment of the Ministry of Health of the Russian Federation (no. АААА-А18-118030790008-7).

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Authors and Affiliations

  1. Novosibirsk State Medical University, Novosibirsk, Russia

    A. I. Autenshlyus & A. A. Studenikina

  2. Institute of Molecular Biology and Biophysics— Subdivision of Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    A. I. Autenshlyus, A. A. Studenikina &  V. V. Lyakhovich

  3. JSC Vector-Best, Novosibirsk, Russia

    N. A. Varaksin

Authors
  1. A. I. Autenshlyus
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  2. A. A. Studenikina
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  3. N. A. Varaksin
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  4. V. V. Lyakhovich
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Correspondence to A. I. Autenshlyus.

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Conflict of interest. The authors declare no obvious and potential conflicts of interest related to the publication of this article.

Statement of compliance with standards of research involving humans as subjects. All studies were conducted in accordance with the Declaration of Helsinki of the World Medical Association. The study was approved by the Ethics Committee of the Research Institute for Molecular Biology and Biophysics, a subdivision of the Federal Research Center of Fundamental and Translational Medicine. All persons participating in the study gave their voluntary informed consent to participate in the study.

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Translated by M. Batrukova

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Autenshlyus, A.I., Studenikina, A.A., Varaksin, N.A. et al. Cytokine Production by Tumor Bioptate at Different Pathological Prognostic Stages in Breast Cancer. Dokl Biochem Biophys 497, 86–89 (2021). https://doi.org/10.1134/S1607672921020010

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  • DOI: https://doi.org/10.1134/S1607672921020010

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